This article applies to macOS. If you are using Windows, please see this article: How to change the sample rate and buffer size on Windows
On Mac, you can set the sample rate for your Focusrite audio interface via the Audio MIDI Setup utility.
Finder →
Applications →
Utilities →
Audio MIDI Setup
However, many applications and DAWs will change the sample rate automatically, overriding the setting in Audio MIDI Setup. Additionally, the buffer size can only be configured within the settings for your DAW or similar applications on Mac.
Check the user guides and support information from the makers of your DAW or other applications to learn how to set the sample rate and buffer size.
If you'd like to know more about what buffer size and sample rate are, check out this article: Sample Rate, Bit Depth, and Buffer Size Explained.
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