This article outlines compatibility information for Apple computers with Apple Silicon processors. For compatibility information regarding Apple computers with Intel processors please see this article. If you're unsure whether you have an "Intel" or "Apple Silicon" system please see this article.
Update: 24th November 2020
At time of writing Focusrite products are not supported on Apple Silicon-based Mac systems as we are aware of some issues.
Once we have completed verification of the compatibility status of our current products we will update this article, until then we would recommend against relying on using such a system in conjunction with your Focusrite product.