Applies to: Scarlett 2nd Gen, Scarlett 3rd Gen users with Pro Tools | First
Yes, since the release of version 2020.9, Pro Tools | First is now compatible with macOS Catalina 10.15.6.
If you wish to stay informed on Pro Tools | First compatibility, please subscribe to the following articles for updates on Avid's support site:
http://avid.force.com/pkb/articles/Compatibility/Pro-Tools-System-Requirements
http://avid.force.com/pkb/articles/FAQ/Pro-Tools-Technical-Alerts-and-Updates