This applies to the Current Saffire Range
Occasionally the permissions for Saffire MixControl will be damaged following the restoration of a backup from Time Machine or Migration Assistant.
This is usually resolved by moving the following file to the trash:
Mac HD > Library > Preferences > Saffire.startup
If you continue to experience problems with Saffire MixControl crashing upon Opening you should get in contact with the support team to further troubleshoot your issue.