Open the Mac AudioMIDISetup utility located in Applications/Utilities. Once the AudioMIDISetup Control Panel appears, you will see several soundcard options including Default Output, and System Output.Change these options from Built-In Audio to Saffire. System Output routes system sounds such as alerts, while Default Output routes audio out of CoreAudio applications.
I've installed Saffire on my Mac, but audio playback still comes out my mac's internal speakers. How do I route audio to the Saffire instead?
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